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In a host cell which carries nucleic acid encoding a transactivator fusion protein of the invention and a nucleotide sequence operatively linked to the tet operator sequence (ie, gene of interest to be transcribed), high level transcription of the nucleotide sequence operatively linked to the tet operator sequence(s) does not occur in the absence of the substituted tetracycline compounds of the invention?
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In a preferred embodiment, the nucleotide sequence encoding the modified tetracycline repressor is selected from nucleotide sequence encoding any of the amino acid sequences of SEQ ID NOS. The Johns Hopkins POC-IT Antibiotic (ABX), clenbuterol usa frantically
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